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Clinical Research

Study 1:“Reflexology: An Intervention for Advanced Breast Cancer”

Completed 2010, NCI grant #R01 CA104883-01A1, $3,127,692, identifier #, NTC01577420

Basic results:

  • Reflexology is safe.

  • Reflexology is a specialized therapy; it is not a foot massage.

  • Significant improvement in dyspnea (shortness of breath) and ability to function in everyday activities such as walking up a flight of stairs or carrying a bag of groceries

Study 2: “Home-Based Symptom Management via Reflexology for Breast Cancer patients” 

Completed April 2018, NCI grant #R01 CA157459-01, approx. $3,000,000. identifier #, NTC01582971

Basic Results-

The total symptom scores showed significant improvement after reflexology. This total symptom improvement was led by the strength of improvements in fatigue and pain. The list of symptoms below were the ones showing improvement in the total symptom score.

  • Pain

  • Nausea/vomiting

  • Disturbed sleep

  • Distress or being upset

  • Shortness of breath

  • Difficulty remembering things

  • Lack of appetite

  • fatigue

  • Dry mouth or sore mouth

  • feeling sad

  • Numbness and tingling

  • Diarrhea/constipation

Study 3: “Using SMART Design to Improve Symptom Management Strategies Among Cancer Patients”

NCI grant # R01 CA193706

2015-2020. Cancer Clinics in Michigan, Chicago, and Arizona worked with this study. Results available soon-

All three studies were multi-site, longitudinal, randomized clinical trials and funded by the National Institutes of Health.

Principal Investigators-
Gwen Wyatt, Ph.D., RN, FAAN
Alla Sikorskii, PhD
(Michigan State University, College of Nursing)

Lead Reflexologist 2008-2016, Chicago cancer clinics & 2016-2020, Michigan, Chicago & Arizona cancer clinics: Sarah Preusker.


JDetermination of Efficacy of Reflexology in Managing Patients with Diabetic Neuropathy: A Randomized Controlled Clinical Trialournal Articles to Studies:

Systematic review and meta-analysis of reflexology for people with multiple sclerosis: Systematic Review and Meta-Analysis

More Information about the Studies:

2017 NIH Article

2018 Booklet Presentation of the NIH Studies

Contact for additional information

Cynthia Hill NBCR


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